Since March 2021, there have been reports from the UK and internationally of an extremely rare condition characterised by thromboembolic events (blood clots) accompanied by thrombocytopenia (low platelets) following the first dose of the AstraZeneca ( AZ) COVID-19 vaccination. The condition that has been reported following COVID-19 vaccination Risk of new ITP or relapse of ITP following COVID-19 vaccinationĪs with all coronavirus (COVID-19) programme resources, this publication is subject to extensive and regular revisions and we recommend linking to the latest version to ensure that you are giving the most up-to-date clinical advice and guidance.Ī range of resources has been developed and updated to support this decision making. Risk of relapse of thrombosis and thrombocytopenia symptoms following subsequent doses of COVID-19 vaccinations What investigations do you need to organise for cases? ![]() Can patients taking the combined oral contraceptive pill have the AZ vaccine? If a patient under 40 years old wants to have the AZ vaccine How to communicate the potential benefits and risks of the AZ vaccine to patients Will taking aspirin before vaccination with the AZ vaccine reduce the clotting risk? Should patients have a second dose of a different vaccine other than the AZ vaccine? If somebody under 40 years has had AZ for their first dose – should they have the second? Can patients still have a second dose of the AZ vaccine if they had a blood clot after the first dose? If someone has had a cerebral or major blood clot with low levels of platelets following the first dose of AZ vaccine Can patients receive the AZ vaccine if they have been or are currently thrombocytopenic? Can patients with antiphospholipid syndrome have the vaccine? Can patients receive the AZ vaccine if they have previously had a blood clot? Contraindications or cautions to receiving the AZ vaccine Is it affecting any particular community? Has this condition been reported after both the first and second dose of COVID-19 vaccine? Can COVID-19 infection cause the same problem? ![]() UK’s current advice on the use of the AZ vaccine Number of people who have developed the condition Is this condition only associated with the AZ vaccine? Risk factors for developing this condition
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